Structure and function of Tec family kinase Itk

Qian Qia; Arun Kumar Kannana; Avery August

doi:10.1515/bmc.2011.020

Structure and function of Tec family kinase Itk

Qian Qia
, Arun Kumar Kannana
, Avery August

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Itk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of iNKT cells. In this review we discuss current progress on our understanding of the structure, activation and signaling pathway of Itk, in addition to inhibitors that have been developed, which target this kinase. We also place in context the function of Itk, available inhibitors and potential use in treating disease.

Original language	English (US)
Pages (from-to)	223-232
Number of pages	10
Journal	Biomolecular Concepts
Volume	2
Issue number	3
DOIs	https://doi.org/10.1515/bmc.2011.020
State	Published - Jun 1 2011

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology
Cellular and Molecular Neuroscience

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10.1515/bmc.2011.020

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title = "Structure and function of Tec family kinase Itk",

abstract = "Itk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of iNKT cells. In this review we discuss current progress on our understanding of the structure, activation and signaling pathway of Itk, in addition to inhibitors that have been developed, which target this kinase. We also place in context the function of Itk, available inhibitors and potential use in treating disease.",

author = "Qian Qia and Kannana, \{Arun Kumar\} and Avery August",

note = "Funding Information: We thank the members of the August lab for their helpful comments. Supported by National Institute of Health grants AI51626, AI065566 and AI073955 to A.A. We apologize to those workers in the field whom we could not directly reference their work due to space limitations. Publisher Copyright: {\textcopyright} Walter de Gruyter Berlin Boston 2011.",

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AU - Qia, Qian

AU - Kannana, Arun Kumar

AU - August, Avery

N1 - Funding Information: We thank the members of the August lab for their helpful comments. Supported by National Institute of Health grants AI51626, AI065566 and AI073955 to A.A. We apologize to those workers in the field whom we could not directly reference their work due to space limitations. Publisher Copyright: © Walter de Gruyter Berlin Boston 2011.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Itk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of iNKT cells. In this review we discuss current progress on our understanding of the structure, activation and signaling pathway of Itk, in addition to inhibitors that have been developed, which target this kinase. We also place in context the function of Itk, available inhibitors and potential use in treating disease.

AB - Itk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of iNKT cells. In this review we discuss current progress on our understanding of the structure, activation and signaling pathway of Itk, in addition to inhibitors that have been developed, which target this kinase. We also place in context the function of Itk, available inhibitors and potential use in treating disease.

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DO - 10.1515/bmc.2011.020

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EP - 232

JO - Biomolecular Concepts

JF - Biomolecular Concepts

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ER -

Structure and function of Tec family kinase Itk

Abstract

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