Structure-function relationships among RNA-dependent RNA polymerases

Kenneth K.S. Ng, Jamie J. Arnold, Craig E. Cameron

Research output: Chapter in Book/Report/Conference proceedingChapter

189 Scopus citations


RNA-dependent RNA polymerases (RdRPs) play key roles in viral transcription and genome replication, as well as epigenetic and post-transcriptional control of cellular gene expression. In this article, we review the crystallographic, biochemical, and molecular genetic data available for viral RdRPs that have led to a detailed description of substrate and cofactor binding, fidelity of nucleotide selection and incorporation, and catalysis. It is likely that the cellular RdRPs will share some of the basic structural and mechanistic principles gleaned from studies of viral RdRPs. Therefore, studies of the viral RdRP establish a framework for the study of cellular RdRPs, an important yet understudied class of nucleic acid polymerases.

Original languageEnglish (US)
Title of host publicationRNA Interference
EditorsPatrick Paddison, Peter Vogt
Number of pages20
StatePublished - 2008

Publication series

NameCurrent Topics in Microbiology and Immunology
ISSN (Print)0070-217X

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)


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