Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site

Keyphrases

• Binding Site 100%
• Ribonucleotides 100%
• Folate 100%
• Carboxamide 100%
• Multisubstrate 100%
• Aminoimidazoles 100%
• Inosine Monophosphate 40%
• Cyclohydrolase 40%
• Active Sites 30%
• Formyl 30%
• Binding Pocket 10%
• Transition State 10%
• Protonation 10%
• Catalytic Steps 10%
• Binding Region 10%
• Leaving Group 10%
• Antineoplastic Agents 10%
• Bifunctional Enzyme 10%
• Synthesis Pathway 10%
• Dimer Interface 10%
• Homodimeric 10%
• 3D Scaffold 10%
• Tetrahydrofolate 10%
• Oxyanions 10%
• 10-Formyltetrahydrofolate 10%

Biochemistry, Genetics and Molecular Biology

• Binding Site 100%
• Folic Acid 100%
• Aves 100%
• Ribonucleotide 100%
• Inosinic Acid 40%
• Active Site 30%
• Crystal Structure 30%
• Enzyme 10%
• Protonation 10%
• Tetrahydrofolic Acid 10%

Chemistry

• Binding Site 100%
• Carboxamide 100%
• Folate 100%
• Aminoimidazole 100%
• Crystal Structure 30%
• Tetrahydrofolate 20%
• Tetrahydrofolic Acid 20%
• Purine 10%
• Transition State 10%
• Donor 10%
• Oxyanion 10%
• protonation 10%
• dimer 10%