Structure of Chicken Annexin V at 2.25-Å Resolution

Maria C. Bewley; Catherine M. Boustead; John H. Walker; David A. Walle; Robert Huber

doi:10.1021/bi00066a011

Structure of Chicken Annexin V at 2.25-Å Resolution

Maria C. Bewley, Catherine M. Boustead, John H. Walker, David A. Walle, Robert Huber

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58 Scopus citations

Abstract

The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 Å. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.

Original language	English (US)
Pages (from-to)	3923-3929
Number of pages	7
Journal	Biochemistry
Volume	32
Issue number	15
DOIs	https://doi.org/10.1021/bi00066a011
State	Published - Apr 1 1993

All Science Journal Classification (ASJC) codes

Biochemistry

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10.1021/bi00066a011

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title = "Structure of Chicken Annexin V at 2.25-{\AA} Resolution",

abstract = "The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 {\AA}. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.",

author = "Bewley, {Maria C.} and Boustead, {Catherine M.} and Walker, {John H.} and Walle, {David A.} and Robert Huber",

year = "1993",

month = apr,

day = "1",

doi = "10.1021/bi00066a011",

language = "English (US)",

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journal = "Biochemistry",

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TY - JOUR

T1 - Structure of Chicken Annexin V at 2.25-Å Resolution

AU - Bewley, Maria C.

AU - Boustead, Catherine M.

AU - Walker, John H.

AU - Walle, David A.

AU - Huber, Robert

PY - 1993/4/1

Y1 - 1993/4/1

N2 - The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 Å. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.

AB - The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 Å. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.

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DO - 10.1021/bi00066a011

M3 - Article

C2 - 8471604

AN - SCOPUS:0027174086

SN - 0006-2960

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SP - 3923

EP - 3929

JO - Biochemistry

JF - Biochemistry

IS - 15

ER -

Structure of Chicken Annexin V at 2.25-Å Resolution

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