Structure of serum response factor core bound to DNA

Luca Pellegrini, Song Tan, Timothy J. Richmond

Research output: Contribution to journalArticlepeer-review

307 Scopus citations


The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.

Original languageEnglish (US)
Pages (from-to)490-498
Number of pages9
Issue number6540
StatePublished - Aug 10 1995

All Science Journal Classification (ASJC) codes

  • General


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