@article{d1dd17f88ded448598d54595ac7d73ed,
title = "Studies of human twins reveal genetic variation that affects dietary fat perception",
abstract = "To learn more about the mechanisms of human dietary fat perception, we asked 398 human twins to rate the fattiness and how much they liked 6 types of potato chips that differed in triglyceride content (2.5%, 5%, 10%, and 15% corn oil); reliability estimates were obtained from a subset (n = 50) who did the task twice. Some chips also had a saturated long-chain fatty acid (FA; hexadecanoic acid, 16:0) added (0.2%) to evaluate its effect on fattiness and liking. We computed the heritability of these measures and conducted a genome-wide association study (GWAS) to identify regions of the genome that co-segregate with fattiness and liking. Perceived fattiness of and liking for the potato chips were reliable (r = 0.31-0.62, P < 0.05) and heritable (up to h2 = 0.29, P < 0.001, for liking). Adding hexadecanoic acid to the potato chips significantly increased ratings of fattiness but decreased liking.Twins with the G allele of rs263429 near GATA3-AS1 or the G allele of rs8103990 within ZNF729 reported more liking for potato chips than did twins with the other allele (multivariate GWAS, P < 1 × 10-5), with results reaching genome-wide suggestive but not significance criteria. Person-to-person variation in the perception and liking of dietary fat was 1) negatively affected by the addition of a saturated FA and 2) related to inborn genetic variants.These data suggest that liking for dietary fat is not due solely to FA content and highlight new candidate genes and proteins within this sensory pathway.",
author = "Cailu Lin and Lauren Colquitt and Paul Wise and Breslin, {Paul A.S.} and Rawson, {Nancy E.} and Federica Genovese and Ivy Maina and Paule Joseph and Lydia Fomuso and Louise Slade and Dennis Brooks and Aur{\'e}lie Miclo and Hayes, {John E.} and Antonio Sullo and Reed, {Danielle R.}",
note = "Funding Information: This work was supported in part by PepsiCo R&D, Diageo and Monell Institutional Funds. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of PepsiCo, Inc., or Diageo. Some genotyping was performed at the Monell DNA and RNA Analysis Core, which is supported, in part, by funding from the National Institutes of Health–National Institute on Deafness and Other Communication Disorders Core Grant 1P30DC011735 using an instrument purchased using National Institutes of Health funds (S10 OD018125). Funding Information: We thank the following people for assistance with data collection, listed in alphabetical order: Charles J. Arayata, Nuala Bobowski, Fujiko Duke, Hillary Ellis, Brad Fesi, Nicole Greenbaum, Aurora Hannikainen, Desmond Johnson, Katherine Leung, Durpri Lin, Alex Mangroo, Corrine Mansfield, Michael Marquis, Elliott McDowell, Tiffany Murray, Lauren Shaw, Lindsey Snyder, Molly Spencer, Amber Suk, Alyssa Treff, and Casey Trimmer. We thank the twins for their participation and the administration of TwinsDays, including Sandy Miller and Janine Bregitzer for their assistance during data collection. We thank two anonymous reviewers for their constructive comments, which improved the quality of this manuscript. This work was supported in part by PepsiCo R&D, Diageo and Monell Institutional Funds. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of PepsiCo, Inc., or Diageo. Some genotyping was performed at the Monell DNA and RNA Analysis Core, which is supported, in part, by funding from the National Institutes of Health-National Institute on Deafness and Other Communication Disorders Core Grant 1P30DC011735 using an instrument purchased using National Institutes of Health funds (S10 OD018125). Funding Information: This study was partially funded by PepsiCo, Inc. PepsiCo, Inc., had no role in the design, execution, interpretation, or writing of the study. L.F. discloses her conflict of interest as she is an employee of PepsiCo, Inc., and claims no other conflicts of interest. This study was also partially funded by Diageo. Diageo had no role in the design, execution, interpretation, or writing of the study. A.S. and D.B. disclose their conflict of interest as they are employees of Diageo and claim no other conflicts of interest. Publisher Copyright: {\textcopyright} The Author(s) 2020. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2020",
month = jul,
day = "7",
doi = "10.1093/chemse/bjaa036",
language = "English (US)",
volume = "45",
pages = "467--481",
journal = "Chemical senses",
issn = "0379-864X",
publisher = "Oxford University Press",
number = "6",
}