Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin

Ajay K. Bose; Shantilal G. Amin; Jagdish C. Kapur; Maghar S. Manhas

doi:10.1039/p19760002193

Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin

Ajay K. Bose, Shantilal G. Amin, Jagdish C. Kapur, Maghar S. Manhas

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Abstract

Several polycyclic β-lactams have been synthesized by the reactions of cyclic imines with acid chlorides in the presence of triethylamine. The azido-functions in these β-lactams were reduced to amino-groups, which were then acylated with phenylacetyl chloride to introduce the penicillin G side chain. Some carbocyclic analogues of cephalosporin were found to possess antibacterial activity.

Original language	English (US)
Pages (from-to)	2193-2197
Number of pages	5
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	20
DOIs	https://doi.org/10.1039/p19760002193
State	Published - 1976

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1039/p19760002193

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title = "Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin",

abstract = "Several polycyclic β-lactams have been synthesized by the reactions of cyclic imines with acid chlorides in the presence of triethylamine. The azido-functions in these β-lactams were reduced to amino-groups, which were then acylated with phenylacetyl chloride to introduce the penicillin G side chain. Some carbocyclic analogues of cephalosporin were found to possess antibacterial activity.",

author = "Bose, \{Ajay K.\} and Amin, \{Shantilal G.\} and Kapur, \{Jagdish C.\} and Manhas, \{Maghar S.\}",

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AU - Kapur, Jagdish C.

AU - Manhas, Maghar S.

PY - 1976

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AB - Several polycyclic β-lactams have been synthesized by the reactions of cyclic imines with acid chlorides in the presence of triethylamine. The azido-functions in these β-lactams were reduced to amino-groups, which were then acylated with phenylacetyl chloride to introduce the penicillin G side chain. Some carbocyclic analogues of cephalosporin were found to possess antibacterial activity.

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Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin

Abstract

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