Studies on pyrazinoylguanidine: 4. Upregulation of phosphodiesterase activity in rat adipose tissue and downregulation of gluconeogenesis and adenosine 3′,5′-monophosphate concentrations in perfused rat liver

Yousif I. A-Rahim, Sharon L. Rannels, Scot R. Kimball, Karl H. Beyer, Elliot S. Vesell

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    In isolated rat adipocytes stimulated with theophylline (1 mmol/l), pyrazinoylguanidine (PZG) downregulated both lipolysis and cyclic AMP concentrations, raising the possibility that PZG stimulates adipose insulin-sensitive phosphodiesterase. To investigate this directly, we measured PZG’s effects on phosphodiesterase activity in rat adipocytes. PZG (10 μmol/l) as well as insulin (0.1–1 mU) increased adipose phosphodiesterase activity, whereas theophylline reduced it. Also investigated were PZG’s effects on gluconeogenesis and cyclic AMP in perfused rat liver where PZG decreased gluconeogenesis and cyclic AMP concentrations.

    Original languageEnglish (US)
    Pages (from-to)211-218
    Number of pages8
    JournalPharmacology
    Volume53
    Issue number4
    DOIs
    StatePublished - Jan 1 1996

    All Science Journal Classification (ASJC) codes

    • Pharmacology

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