TY - JOUR
T1 - Studies on serum stimulation of mouse fibroblast migration
AU - Wolf, L.
AU - Lipton, A.
N1 - Funding Information:
We wish to thank Dr R. W. Holley and Miss lngrid Klinger for their suggestiont o pursue this study and for many stimulatingd iscussions. This investigation was supported by a research grant from ACS (no. VC-78) (William Rankin and Elizabeth Forbes Rankin Memorial grant for Cancer Research).
PY - 1973/8
Y1 - 1973/8
N2 - Evidence is presented that the factor present in rat serum that promotes the migration of mouse fibroblasts (3T3) is a high mol. wt molecule. Amino acids, Mg2+ and Ca2+ are essential for full expression of activity. Once exposed to serum there is an 8-10 h lag period before cell migration can be detected. Cycloheximide, velban, colchicine, actinomycin D, and cytochalasin B, all inhibit cellular migration from a wound edge.
AB - Evidence is presented that the factor present in rat serum that promotes the migration of mouse fibroblasts (3T3) is a high mol. wt molecule. Amino acids, Mg2+ and Ca2+ are essential for full expression of activity. Once exposed to serum there is an 8-10 h lag period before cell migration can be detected. Cycloheximide, velban, colchicine, actinomycin D, and cytochalasin B, all inhibit cellular migration from a wound edge.
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U2 - 10.1016/0014-4827(73)90334-0
DO - 10.1016/0014-4827(73)90334-0
M3 - Article
C2 - 4745393
AN - SCOPUS:0015891911
SN - 0014-4827
VL - 80
SP - 499
EP - 502
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 2
ER -