Studies on serum stimulation of mouse fibroblast migration

L. Wolf; A. Lipton

doi:10.1016/0014-4827(73)90334-0

Studies on serum stimulation of mouse fibroblast migration

L. Wolf
, A. Lipton

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Evidence is presented that the factor present in rat serum that promotes the migration of mouse fibroblasts (3T3) is a high mol. wt molecule. Amino acids, Mg²⁺ and Ca²⁺ are essential for full expression of activity. Once exposed to serum there is an 8-10 h lag period before cell migration can be detected. Cycloheximide, velban, colchicine, actinomycin D, and cytochalasin B, all inhibit cellular migration from a wound edge.

Original language	English (US)
Pages (from-to)	499-502
Number of pages	4
Journal	Experimental Cell Research
Volume	80
Issue number	2
DOIs	https://doi.org/10.1016/0014-4827(73)90334-0
State	Published - Aug 1973

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1016/0014-4827(73)90334-0

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@article{ed49fc53a4d544ca8ee9c6dbee335de7,

title = "Studies on serum stimulation of mouse fibroblast migration",

abstract = "Evidence is presented that the factor present in rat serum that promotes the migration of mouse fibroblasts (3T3) is a high mol. wt molecule. Amino acids, Mg2+ and Ca2+ are essential for full expression of activity. Once exposed to serum there is an 8-10 h lag period before cell migration can be detected. Cycloheximide, velban, colchicine, actinomycin D, and cytochalasin B, all inhibit cellular migration from a wound edge.",

author = "L. Wolf and A. Lipton",

note = "Funding Information: We wish to thank Dr R. W. Holley and Miss lngrid Klinger for their suggestiont o pursue this study and for many stimulatingd iscussions. This investigation was supported by a research grant from ACS (no. VC-78) (William Rankin and Elizabeth Forbes Rankin Memorial grant for Cancer Research).",

year = "1973",

month = aug,

doi = "10.1016/0014-4827(73)90334-0",

language = "English (US)",

volume = "80",

pages = "499--502",

journal = "Experimental Cell Research",

issn = "0014-4827",

publisher = "Elsevier Inc.",

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T1 - Studies on serum stimulation of mouse fibroblast migration

AU - Wolf, L.

AU - Lipton, A.

N1 - Funding Information: We wish to thank Dr R. W. Holley and Miss lngrid Klinger for their suggestiont o pursue this study and for many stimulatingd iscussions. This investigation was supported by a research grant from ACS (no. VC-78) (William Rankin and Elizabeth Forbes Rankin Memorial grant for Cancer Research).

PY - 1973/8

Y1 - 1973/8

N2 - Evidence is presented that the factor present in rat serum that promotes the migration of mouse fibroblasts (3T3) is a high mol. wt molecule. Amino acids, Mg2+ and Ca2+ are essential for full expression of activity. Once exposed to serum there is an 8-10 h lag period before cell migration can be detected. Cycloheximide, velban, colchicine, actinomycin D, and cytochalasin B, all inhibit cellular migration from a wound edge.

AB - Evidence is presented that the factor present in rat serum that promotes the migration of mouse fibroblasts (3T3) is a high mol. wt molecule. Amino acids, Mg2+ and Ca2+ are essential for full expression of activity. Once exposed to serum there is an 8-10 h lag period before cell migration can be detected. Cycloheximide, velban, colchicine, actinomycin D, and cytochalasin B, all inhibit cellular migration from a wound edge.

UR - https://www.scopus.com/pages/publications/0015891911

UR - https://www.scopus.com/pages/publications/0015891911#tab=citedBy

U2 - 10.1016/0014-4827(73)90334-0

DO - 10.1016/0014-4827(73)90334-0

M3 - Article

C2 - 4745393

AN - SCOPUS:0015891911

SN - 0014-4827

VL - 80

SP - 499

EP - 502

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 2

ER -

Studies on serum stimulation of mouse fibroblast migration

Abstract

All Science Journal Classification (ASJC) codes

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