TY - JOUR
T1 - Study of nasal exhaled nitric oxide levels in diagnosis of allergic rhinitis in subjects with and without asthma
AU - Duong-Quy, Sy
AU - Vu-Minh, Thuc
AU - Hua-Huy, Thong
AU - Tang-Thi-Thao, Tram
AU - Le-Quang, Khiet
AU - Tran-Thanh, Dinh
AU - Doan-Thi-Quynh, Nhu
AU - Le-Dong, Nhat Nam
AU - Craig, Timothy J.
AU - Dinh-Xuan, Anh Tuan
N1 - Publisher Copyright:
© 2017 Duong-Quy et al.
PY - 2017/3/22
Y1 - 2017/3/22
N2 - Background: The measure of fractional exhaled nitric oxide (FENO) in the airways is a useful tool to guide the diagnosis and titration of inhaled corticosteroids in patients with asthma. However, its role in diagnosis of allergic rhinitis (AR), especially in subjects with asthma, is not well established. Objective: To study the cutoff of nasal FENO in the diagnosis of subjects with AR and ARasthma compared to age-matched subjects without AR or asthma and its correlations with the clinical and functional characteristics. Methods: The study was cross sectional and descriptive. Subjects were grouped into control subjects, AR, and AR-asthma, based on the inclusion criteria. Exhaled NO (nasal FENO, bronchial FENO, and alveolar concentration of NO) was measured by multiple flow electroluminescence device. Results: Six hundred twenty-eight subjects were included: 217 control subjects (children: n=98, 10±4 years; adults: n=119, 50±16 years), 168 subjects with AR (children: n=54, 10±3 years; adults: n=114, 49±15 years), and 243 subjects with AR-asthma (children: n=115, 10±3 years; adults: n=128, 51±14 years). Nasal peak inspiratory flow and peak expiratory flow were lower in subjects with AR and AR-asthma than in control subjects (P<0.01 and P<0.01; and P<0.05 and P<0.01, respectively). Nasal FENO levels were significantly higher in subjects with AR and AR-asthma than in control subjects (1614±629 and 1686±614 ppb vs 582±161 ppb; P<0.001 and P<0.001, respectively). In subjects with AR non-asthma, the cutoffs of nasal FENO for those diagnosed with AR were 775 ppb in children, 799 ppb in adults, and 799 in the general population (sensitivity: 92.68%, 92.63%, and 92.65%, respectively; specificity: 91.67%, 95.00%, and 96.87%, respectively). In subjects with AR-asthma, the cutoffs of nasal FENO were higher, especially in asthma children (1458 ppb; sensitivity: 72.97% and specificity: 95.83%). Conclusion: Nasal FENO measurement is a useful technique for the diagnosis of AR in subjects with and without asthma.
AB - Background: The measure of fractional exhaled nitric oxide (FENO) in the airways is a useful tool to guide the diagnosis and titration of inhaled corticosteroids in patients with asthma. However, its role in diagnosis of allergic rhinitis (AR), especially in subjects with asthma, is not well established. Objective: To study the cutoff of nasal FENO in the diagnosis of subjects with AR and ARasthma compared to age-matched subjects without AR or asthma and its correlations with the clinical and functional characteristics. Methods: The study was cross sectional and descriptive. Subjects were grouped into control subjects, AR, and AR-asthma, based on the inclusion criteria. Exhaled NO (nasal FENO, bronchial FENO, and alveolar concentration of NO) was measured by multiple flow electroluminescence device. Results: Six hundred twenty-eight subjects were included: 217 control subjects (children: n=98, 10±4 years; adults: n=119, 50±16 years), 168 subjects with AR (children: n=54, 10±3 years; adults: n=114, 49±15 years), and 243 subjects with AR-asthma (children: n=115, 10±3 years; adults: n=128, 51±14 years). Nasal peak inspiratory flow and peak expiratory flow were lower in subjects with AR and AR-asthma than in control subjects (P<0.01 and P<0.01; and P<0.05 and P<0.01, respectively). Nasal FENO levels were significantly higher in subjects with AR and AR-asthma than in control subjects (1614±629 and 1686±614 ppb vs 582±161 ppb; P<0.001 and P<0.001, respectively). In subjects with AR non-asthma, the cutoffs of nasal FENO for those diagnosed with AR were 775 ppb in children, 799 ppb in adults, and 799 in the general population (sensitivity: 92.68%, 92.63%, and 92.65%, respectively; specificity: 91.67%, 95.00%, and 96.87%, respectively). In subjects with AR-asthma, the cutoffs of nasal FENO were higher, especially in asthma children (1458 ppb; sensitivity: 72.97% and specificity: 95.83%). Conclusion: Nasal FENO measurement is a useful technique for the diagnosis of AR in subjects with and without asthma.
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U2 - 10.2147/JAA.S129047
DO - 10.2147/JAA.S129047
M3 - Article
C2 - 28356764
AN - SCOPUS:85016333887
SN - 1178-6965
VL - 10
SP - 75
EP - 82
JO - Journal of Asthma and Allergy
JF - Journal of Asthma and Allergy
ER -