Suboptimal response following intradermal hepatitis B vaccine in infants

Jacqueline S. Coberly, Timothy Townsend, John Repke, Howard Fields, Harold Margolis, Neal A. Halsey

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Two hundred and twenty-five infants were randomly assigned to receive 2 μg of plasma-derived hepatitis B vaccine (Heptavax) intradermally (ID-2), 10 μg intramuscularly (IM-10), or 2 μg intramuscularly (IM-2) in the deltoid region at birth, 2 and 4 months. At 6 months, ID-2 infants were less likely to have developed ≥ 10 mIU ml-1 of antibody to hepatitis B surface antigen (anti-HBs) than IM-10 infants (91 versus 100%; p=0.02) and had a lower geometric mean concentration of anti-HBs (312 mIU ml- versus 2248 mIU ml-1; p < 0.01). At 6 months IM-10 infants had significantly lower mean weights and lengths than infants receiving 2 μg doses of vaccine. Intramuscular administration of 2 μg and 10 μg doses of Heptavax in the deltoid of young infants was well tolerated and effective; however, intradermal administration of Heptavax provided no immunological benefit over intramuscular administration and resulted in significantly higher rates of induration and persistent hyperpigmentation. Intramuscular immunization at birth, 2 and 4 months is an acceptable, effective alternative schedule for immunizing infants.

Original languageEnglish (US)
Pages (from-to)984-987
Number of pages4
Issue number11
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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