TY - JOUR
T1 - Substance P, Hexapeptide pGlu6(SP6-11), analgesia and serotonin depletion
AU - Mészáros, J.
AU - Tarchalska, B.
AU - Gajewska, S.
AU - Janicki, P.
AU - Duriasz, H.
AU - Szreniawski, Z.
N1 - Funding Information:
1This work was supported by Polish Academy of Sciences, Grant No. 10,4. Part of the results was presented at IBRO symposium Neuropeptides and Neural Transmission, Jablonna k/Warszawy, Poland, 1979.
PY - 1981/1
Y1 - 1981/1
N2 - Substance P caused marked analgesic activity in rats after intraventricular administration and in mice after intraperitoneal injection. The hexapeptide pGlu6(SP6-11) was active in mice, but not in rats. Depletion of serotonin with p-chlorophenylalanine abolished the antinociceptive activity in mice, but not in rats, whereas lesion of raphe nuclei blocked the activity of substance P in the latter animals. Although different routes of administration were used, the results seem to indicate different mechanisms of analgesic activity of both peptides in rats and mice, as well as the different role of serotonergic transmission in pain control mechanisms in both species.
AB - Substance P caused marked analgesic activity in rats after intraventricular administration and in mice after intraperitoneal injection. The hexapeptide pGlu6(SP6-11) was active in mice, but not in rats. Depletion of serotonin with p-chlorophenylalanine abolished the antinociceptive activity in mice, but not in rats, whereas lesion of raphe nuclei blocked the activity of substance P in the latter animals. Although different routes of administration were used, the results seem to indicate different mechanisms of analgesic activity of both peptides in rats and mice, as well as the different role of serotonergic transmission in pain control mechanisms in both species.
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U2 - 10.1016/0091-3057(81)90096-4
DO - 10.1016/0091-3057(81)90096-4
M3 - Article
C2 - 6162166
AN - SCOPUS:0019461698
SN - 0091-3057
VL - 14
SP - 11
EP - 15
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 1
ER -