Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

T. Hamaki; H. Katori; T. Kami; T. Yamato; H. Yamakado; T. Itoh; E. Kusumi; M. Igarshi; J. Ueyama; Y. Kanda; S. Miyakoshi; S. Mineishi; S. Morinaga; M. Mukai; M. Hayashi; Y. Takaue; S. Hara; Y. Mutou

doi:10.1038/sj.bmt.1703584

Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

T. Hamaki, H. Katori, T. Kami, T. Yamato, H. Yamakado, T. Itoh, E. Kusumi, M. Igarshi, J. Ueyama, Y. Kanda, S. Miyakoshi, S. Mineishi, S. Morinaga, M. Mukai, M. Hayashi, Y. Takaue, S. Hara, Y. Mutou

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17 Scopus citations

Abstract

A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.

Original language	English (US)
Pages (from-to)	195-198
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	30
Issue number	3
DOIs	https://doi.org/10.1038/sj.bmt.1703584
State	Published - 2002

All Science Journal Classification (ASJC) codes

Hematology
Transplantation

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Hamaki, T., Katori, H., Kami, T., Yamato, T., Yamakado, H., Itoh, T., Kusumi, E., Igarshi, M., Ueyama, J., Kanda, Y., Miyakoshi, S., Mineishi, S., Morinaga, S., Mukai, M., Hayashi, M., Takaue, Y., Hara, S., & Mutou, Y. (2002). Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis. Bone Marrow Transplantation, 30(3), 195-198. https://doi.org/10.1038/sj.bmt.1703584

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title = "Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis",

abstract = "A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.",

author = "T. Hamaki and H. Katori and T. Kami and T. Yamato and H. Yamakado and T. Itoh and E. Kusumi and M. Igarshi and J. Ueyama and Y. Kanda and S. Miyakoshi and S. Mineishi and S. Morinaga and M. Mukai and M. Hayashi and Y. Takaue and S. Hara and Y. Mutou",

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Hamaki, T, Katori, H, Kami, T, Yamato, T, Yamakado, H, Itoh, T, Kusumi, E, Igarshi, M, Ueyama, J, Kanda, Y, Miyakoshi, S, Mineishi, S, Morinaga, S, Mukai, M, Hayashi, M, Takaue, Y, Hara, S & Mutou, Y 2002, 'Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis', Bone Marrow Transplantation, vol. 30, no. 3, pp. 195-198. https://doi.org/10.1038/sj.bmt.1703584

TY - JOUR

T1 - Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

AU - Hamaki, T.

AU - Katori, H.

AU - Kami, T.

AU - Yamato, T.

AU - Yamakado, H.

AU - Itoh, T.

AU - Kusumi, E.

AU - Igarshi, M.

AU - Ueyama, J.

AU - Kanda, Y.

AU - Miyakoshi, S.

AU - Mineishi, S.

AU - Morinaga, S.

AU - Mukai, M.

AU - Hayashi, M.

AU - Takaue, Y.

AU - Hara, S.

AU - Mutou, Y.

PY - 2002

Y1 - 2002

N2 - A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.

AB - A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.

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Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

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