TY - JOUR
T1 - Successful Medical Adrenalectomy With Amino-glutethimide
T2 - Role of Altered Drug Metabolism
AU - Santen, Richard J.
AU - Lipton, Allan
AU - Kendall, John
PY - 1974/12/23
Y1 - 1974/12/23
N2 - We used amino-glutethimide and dexamethasone in patients with carcinoma of the breast to abolish adrenal steroidogenesis. Initial studies with this approach, however, did not result in complete adrenal suppression and suggested the possibility of accelerated dexamethasone metabolism. The observation of a twofold reduction in H dexamethasone half-life during amino-glutethimide therapy confirmed this hypothesis. Larger doses of dexamethasone (1.5 to 3.0 mg/day) were administered to 22 patients receiving 1 to 2 gm of amino-glutethimide daily to compensate for rapid dexamethasone metabolism. Complete adrenal suppression for as long as 19 months was then observed, with objective tumor regression in eight subjects and relief of bone pain in three others without producing cushingoid side effects.
AB - We used amino-glutethimide and dexamethasone in patients with carcinoma of the breast to abolish adrenal steroidogenesis. Initial studies with this approach, however, did not result in complete adrenal suppression and suggested the possibility of accelerated dexamethasone metabolism. The observation of a twofold reduction in H dexamethasone half-life during amino-glutethimide therapy confirmed this hypothesis. Larger doses of dexamethasone (1.5 to 3.0 mg/day) were administered to 22 patients receiving 1 to 2 gm of amino-glutethimide daily to compensate for rapid dexamethasone metabolism. Complete adrenal suppression for as long as 19 months was then observed, with objective tumor regression in eight subjects and relief of bone pain in three others without producing cushingoid side effects.
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U2 - 10.1001/jama.1974.03240120029015
DO - 10.1001/jama.1974.03240120029015
M3 - Article
C2 - 4373589
AN - SCOPUS:0016144225
SN - 0098-7484
VL - 230
SP - 1661
EP - 1665
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 12
ER -