TY - JOUR
T1 - Sucrose sham feeding decreases accumbens norepinephrine in the rat
AU - Hajnal, Andras
AU - Norgren, Ralph
N1 - Funding Information:
The authors thank Mr. N. Acharya for his help with the microdialysis and HPLC, and Ms. K. Matyas and N. Horvath for the histology. This research was supported by NIH grants DC 04751, DK 065709, DC00240.
PY - 2004/8
Y1 - 2004/8
N2 - Noradrenergic projections from the dorsomedial medulla reach the shell of the nucleus accumbens (NAcc), a structure implicated in both reward and feeding behavior. Despite this relationship, the effect of food reward on accumbens norepinephrine (NE) remains uninvestigated. In the course of assessing dopamine (DA) in the NAcc during sucrose ingestion [0.03, 0.1, and 0.3 M; Am. J. Physiol., Regul. Integr. Comp. Physiol., 286 (2004) R31], we also analyzed NE in the microdialysis samples from 14 ad-libitum-fed male rats. In contrast to DA, which increased with sucrose concentration (+20-47%) during sham feeding, in the same animals, NE levels were reduced (approximately -20%), regardless of sucrose concentration. These results demonstrate a novel relationship between accumbens DA and NE during orosensory stimulation with a preferred nutrient.
AB - Noradrenergic projections from the dorsomedial medulla reach the shell of the nucleus accumbens (NAcc), a structure implicated in both reward and feeding behavior. Despite this relationship, the effect of food reward on accumbens norepinephrine (NE) remains uninvestigated. In the course of assessing dopamine (DA) in the NAcc during sucrose ingestion [0.03, 0.1, and 0.3 M; Am. J. Physiol., Regul. Integr. Comp. Physiol., 286 (2004) R31], we also analyzed NE in the microdialysis samples from 14 ad-libitum-fed male rats. In contrast to DA, which increased with sucrose concentration (+20-47%) during sham feeding, in the same animals, NE levels were reduced (approximately -20%), regardless of sucrose concentration. These results demonstrate a novel relationship between accumbens DA and NE during orosensory stimulation with a preferred nutrient.
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U2 - 10.1016/j.physbeh.2004.04.024
DO - 10.1016/j.physbeh.2004.04.024
M3 - Article
C2 - 15234588
AN - SCOPUS:3242754993
SN - 0031-9384
VL - 82
SP - 43
EP - 47
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 1
ER -