1H indirect detected 13C low-abundance single-transition correlation spectroscopy (HICLASS)-13C homonuclear correlation at natural abundance

Christy George; N. Chandrakumar

doi:10.1021/ol2025058

¹H indirect detected ¹³C low-abundance single-transition correlation spectroscopy (HICLASS)-¹³C homonuclear correlation at natural abundance

Christy George, N. Chandrakumar

Chemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A novel proton-detected ¹³C homonuclear correlation experiment is reported at natural abundance, viz., ¹H Indirect detected ¹³C Low-Abundance Single-transition correlation Spectroscopy (HICLASS). HICLASS is based on the evolution of ¹³C single-quantum single transitions, followed by their mixing, and ¹H detection subsequent to heteronuclear transfer. Reduced relaxation losses during the evolution time and partial selectivity in the ¹H multiplet structure result in enhanced sensitivity of HICLASS. The superior performance of HICLASS is demonstrated for ¹H-detected ¹³C correlation work.

Original language	English (US)
Pages (from-to)	5448-5451
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	20
DOIs	https://doi.org/10.1021/ol2025058
State	Published - Oct 21 2011

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol2025058

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title = "1H indirect detected 13C low-abundance single-transition correlation spectroscopy (HICLASS)-13C homonuclear correlation at natural abundance",

abstract = "A novel proton-detected 13C homonuclear correlation experiment is reported at natural abundance, viz., 1H Indirect detected 13C Low-Abundance Single-transition correlation Spectroscopy (HICLASS). HICLASS is based on the evolution of 13C single-quantum single transitions, followed by their mixing, and 1H detection subsequent to heteronuclear transfer. Reduced relaxation losses during the evolution time and partial selectivity in the 1H multiplet structure result in enhanced sensitivity of HICLASS. The superior performance of HICLASS is demonstrated for 1H-detected 13C correlation work.",

author = "Christy George and N. Chandrakumar",

year = "2011",

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doi = "10.1021/ol2025058",

language = "English (US)",

volume = "13",

pages = "5448--5451",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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AU - George, Christy

AU - Chandrakumar, N.

PY - 2011/10/21

Y1 - 2011/10/21

N2 - A novel proton-detected 13C homonuclear correlation experiment is reported at natural abundance, viz., 1H Indirect detected 13C Low-Abundance Single-transition correlation Spectroscopy (HICLASS). HICLASS is based on the evolution of 13C single-quantum single transitions, followed by their mixing, and 1H detection subsequent to heteronuclear transfer. Reduced relaxation losses during the evolution time and partial selectivity in the 1H multiplet structure result in enhanced sensitivity of HICLASS. The superior performance of HICLASS is demonstrated for 1H-detected 13C correlation work.

AB - A novel proton-detected 13C homonuclear correlation experiment is reported at natural abundance, viz., 1H Indirect detected 13C Low-Abundance Single-transition correlation Spectroscopy (HICLASS). HICLASS is based on the evolution of 13C single-quantum single transitions, followed by their mixing, and 1H detection subsequent to heteronuclear transfer. Reduced relaxation losses during the evolution time and partial selectivity in the 1H multiplet structure result in enhanced sensitivity of HICLASS. The superior performance of HICLASS is demonstrated for 1H-detected 13C correlation work.

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JO - Organic Letters

JF - Organic Letters

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¹H indirect detected ¹³C low-abundance single-transition correlation spectroscopy (HICLASS)-¹³C homonuclear correlation at natural abundance

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