Surface acoustic wave microfluidics

Xiaoyun Ding, Peng Li, Sz Chin Steven Lin, Zackary S. Stratton, Nitesh Nama, Feng Guo, Daniel Slotcavage, Xiaole Mao, Jinjie Shi, Francesco Costanzo, Tony Jun Huang

Research output: Contribution to journalReview articlepeer-review

700 Scopus citations


The recent introduction of surface acoustic wave (SAW) technology onto lab-on-a-chip platforms has opened a new frontier in microfluidics. The advantages provided by such SAW microfluidics are numerous: simple fabrication, high biocompatibility, fast fluid actuation, versatility, compact and inexpensive devices and accessories, contact-free particle manipulation, and compatibility with other microfluidic components. We believe that these advantages enable SAW microfluidics to play a significant role in a variety of applications in biology, chemistry, engineering and medicine. In this review article, we discuss the theory underpinning SAWs and their interactions with particles and the contacting fluids in which they are suspended. We then review the SAW-enabled microfluidic devices demonstrated to date, starting with devices that accomplish fluid mixing and transport through the use of travelling SAW; we follow that by reviewing the more recent innovations achieved with standing SAW that enable such actions as particle/cell focusing, sorting and patterning. Finally, we look forward and appraise where the discipline of SAW microfluidics could go next.

Original languageEnglish (US)
Pages (from-to)3626-3649
Number of pages24
JournalLab on a Chip
Issue number18
StatePublished - Sep 21 2013

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • General Chemistry
  • Biomedical Engineering


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