Surfactant protein A stimulation of inflammatory cytokine and immunoglobulin production

S. G. Kremlev, D. S. Phelps

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141 Scopus citations


Pulmonary surfactant plays a variety of roles related to the regulation of immune function in the lung. Of particular interest in this regard is surfactant protein A (SP-A), a calcium-dependent lectin. We have reported previously that SP-A enhances concanavalin A-induced proliferation, and in this study we examined the secretion of tumor necrosis factor-α (TNF-α), interleukins 1α, 1β, and 6, and interferon-γ by human peripheral blood mononuclear cells. Levels of all of the cytokines except interferon-γ were increased by SP-A. In rat peripheral blood cells, splenocytes, and alveolar macrophages we found a similar enhancement of TNF-α release by SP-A. In combinations of SP-A and surfactant lipids, the increased levels of TNF-α resulting from SP-A treatment decreased as the lipids increased. At higher relative concentrations of SP-A, the lipids had little or no effect. SP-A also enhanced the production of immunoglobulins A, G, and M by rat splenocytes. Levels of each isotype were increased severalfold over control levels. These data demonstrate that SP-A is capable of modulating immune cell function in the lung by regulating cytokine production and immunoglobulin secretion.

Original languageEnglish (US)
Pages (from-to)L712-L719
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Issue number6 11-6
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology


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