Swiprosin-1: Its Expression and Diverse Biological Functions

Ramesh P. Thylur; Raghavendra Gowda; Sumita Mishra; Chang Duk Jun

doi:10.1002/jcb.26199

Swiprosin-1: Its Expression and Diverse Biological Functions

Ramesh P. Thylur, Raghavendra Gowda, Sumita Mishra, Chang Duk Jun

Department of Pharmacology

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18 Scopus citations

Abstract

Swiprosin-1/EFhd2 is a Ca²⁺ binding adapter protein involved in the various cellular functions. Swiprosin-1 is significantly upregulated in a number of pathological conditions of inflammation, neurodegeneration, and cancer. Swiprosin-1 associated with actin and its expression level amplifies the production of proinflammatory mediators and modulates the activation of transcription factor during immune cells activation. This review aims at providing an overview of the expression and function of swiprosin-1/EFhd2 in various pathophysiological conditions. We also discussed the key role of swiprosin-1 in immune cell activation, cell migration, apoptosis, humoral immunity, cancer invasion and metastasis, neuronal transport, and major signaling cascades. J. Cell. Biochem. 119: 150–156, 2018.

Original language	English (US)
Pages (from-to)	150-156
Number of pages	7
Journal	Journal of cellular biochemistry
Volume	119
Issue number	1
DOIs	https://doi.org/10.1002/jcb.26199
State	Published - Jan 2018

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Swiprosin-1/EFhd2 is a Ca2+ binding adapter protein involved in the various cellular functions. Swiprosin-1 is significantly upregulated in a number of pathological conditions of inflammation, neurodegeneration, and cancer. Swiprosin-1 associated with actin and its expression level amplifies the production of proinflammatory mediators and modulates the activation of transcription factor during immune cells activation. This review aims at providing an overview of the expression and function of swiprosin-1/EFhd2 in various pathophysiological conditions. We also discussed the key role of swiprosin-1 in immune cell activation, cell migration, apoptosis, humoral immunity, cancer invasion and metastasis, neuronal transport, and major signaling cascades. J. Cell. Biochem. 119: 150–156, 2018.",

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Swiprosin-1: Its Expression and Diverse Biological Functions

Abstract

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