TY - JOUR
T1 - Symptom clusters in patients with high-grade glioma
T2 - Clinical scholarship
AU - Fox, Sherry W.
AU - Lyon, Debra
AU - Farace, Elana
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Purpose: To describe the co-occurring symptoms (depression, fatigue, pain, sleep disturbance, and cognitive impairment), quality of life (QoL), and functional status in patients with high-grade glioma. Design: Correlational, descriptive study of 73 participants with high-grade glioma in the U.S. Methods: Nine brief measures were obtained with a mailed survey. Participants were recruited from the online message board of The Healing Exchange BRAIN TRUST, a nonprofit organization dedicated to improving quality of life for people with brain tumors. Findings: Two symptom cluster models were examined. Four co-occurring symptoms were significantly correlated with each other and explained 29% of the variance in QoL: depression, fatigue, sleep disturbance, and cognitive impairment. Depression, fatigue, sleep disturbance, cognitive impairment, and pain were significantly correlated with each other and explained 62% of the variance in functional status. Conclusions: The interrelationships of the symptoms examined in this study and their relationships with QoL and functional status meet the criteria for defining a symptom cluster. The differences in the models of QoL and functional status indicates that symptom clusters may have unique characteristics in patients with gliomas.
AB - Purpose: To describe the co-occurring symptoms (depression, fatigue, pain, sleep disturbance, and cognitive impairment), quality of life (QoL), and functional status in patients with high-grade glioma. Design: Correlational, descriptive study of 73 participants with high-grade glioma in the U.S. Methods: Nine brief measures were obtained with a mailed survey. Participants were recruited from the online message board of The Healing Exchange BRAIN TRUST, a nonprofit organization dedicated to improving quality of life for people with brain tumors. Findings: Two symptom cluster models were examined. Four co-occurring symptoms were significantly correlated with each other and explained 29% of the variance in QoL: depression, fatigue, sleep disturbance, and cognitive impairment. Depression, fatigue, sleep disturbance, cognitive impairment, and pain were significantly correlated with each other and explained 62% of the variance in functional status. Conclusions: The interrelationships of the symptoms examined in this study and their relationships with QoL and functional status meet the criteria for defining a symptom cluster. The differences in the models of QoL and functional status indicates that symptom clusters may have unique characteristics in patients with gliomas.
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U2 - 10.1111/j.1547-5069.2007.00144.x
DO - 10.1111/j.1547-5069.2007.00144.x
M3 - Article
C2 - 17393967
AN - SCOPUS:33847209622
SN - 1527-6546
VL - 39
SP - 61
EP - 67
JO - Journal of Nursing Scholarship
JF - Journal of Nursing Scholarship
IS - 1
ER -