Symptomatic manganese neurotoxicity in a patient with chronic liver disease: Correlation of clinical symptoms with MRI findings

Todd F. Barron; Attila G. Devenyi; Alexander C. Mamourian

doi:10.1016/0887-8994(94)90047-7

Symptomatic manganese neurotoxicity in a patient with chronic liver disease: Correlation of clinical symptoms with MRI findings

Todd F. Barron, Attila G. Devenyi, Alexander C. Mamourian

Department of Radiology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Hyperintense symmetric pallidal lesions have been described in chronic hepatic failure. Similar lesions are reported in experimental models of manganese neurotoxicity. We describe an 8-year-old girl with chronic hepatic failure and dystonia in association with an elevated whole blood manganese level and symmetric hyperintense pallidal lesions on magnetic resonance imaging. After hepatic transplantation, her symptoms and signs resolved with normalization of magnetic resonance imaging and the whole blood manganese suggesting that in chronic hepatic failure, the pallidal lesions may be secondary to manganese deposition.

Original language	English (US)
Pages (from-to)	145-148
Number of pages	4
Journal	Pediatric Neurology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/0887-8994(94)90047-7
State	Published - Mar 1994

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Neurology
Developmental Neuroscience
Clinical Neurology

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abstract = "Hyperintense symmetric pallidal lesions have been described in chronic hepatic failure. Similar lesions are reported in experimental models of manganese neurotoxicity. We describe an 8-year-old girl with chronic hepatic failure and dystonia in association with an elevated whole blood manganese level and symmetric hyperintense pallidal lesions on magnetic resonance imaging. After hepatic transplantation, her symptoms and signs resolved with normalization of magnetic resonance imaging and the whole blood manganese suggesting that in chronic hepatic failure, the pallidal lesions may be secondary to manganese deposition.",

author = "Barron, {Todd F.} and Devenyi, {Attila G.} and Mamourian, {Alexander C.}",

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AU - Mamourian, Alexander C.

PY - 1994/3

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AB - Hyperintense symmetric pallidal lesions have been described in chronic hepatic failure. Similar lesions are reported in experimental models of manganese neurotoxicity. We describe an 8-year-old girl with chronic hepatic failure and dystonia in association with an elevated whole blood manganese level and symmetric hyperintense pallidal lesions on magnetic resonance imaging. After hepatic transplantation, her symptoms and signs resolved with normalization of magnetic resonance imaging and the whole blood manganese suggesting that in chronic hepatic failure, the pallidal lesions may be secondary to manganese deposition.

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Symptomatic manganese neurotoxicity in a patient with chronic liver disease: Correlation of clinical symptoms with MRI findings

Abstract

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