Abstract
The response of differentiating MEL cells to the nucleotide analogue cordycepin reveals a previously unrecognized aspect of the molecular events which cause commitment of these cells to terminal erythroid differentiation. Cordycepin rapidly inhibits commitment of DMSO-treated MEL cells in a dose range which does not cause cytotoxicity. Reversal of cordycepin treatment in the presence of inducer leads to a rapid and synchronous commitment of a significant proportion of cells in the culture. These results suggest that MEL cells can be blocked just prior to the point of commitment by cordycepin treatment.
Original language | English (US) |
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Pages (from-to) | 1073-1078 |
Number of pages | 6 |
Journal | Cell |
Volume | 18 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1979 |
All Science Journal Classification (ASJC) codes
- General Biochemistry, Genetics and Molecular Biology