Synergism of lorazepam and electroconvulsive therapy in the treatment of catatonia

Georgios Petrides, Krishna M. Divadeenam, George Bush, Andrew Francis

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


Electroconvulsive therapy (ECT) and lorazepam are effective treatments for catatonia. ECT combined with benzodiazepines has been associated with reduced efficacy and efficiency and therefore is not recommended in the routine practice of ECT. We report 5 prospectively identified cases of catatonia treated either sequentially or concurrently with lorazepam and ECT. In each case, the combination of lorazepam with ECT was superior to monotherapy. This apparent synergism, its possible mechanisms, and its implications for treating catatonia are discussed.

Original languageEnglish (US)
Pages (from-to)375-381
Number of pages7
JournalBiological Psychiatry
Issue number5
StatePublished - Sep 1 1997

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry


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