Synergism of lorazepam and electroconvulsive therapy in the treatment of catatonia

Georgios Petrides; Krishna M. Divadeenam; George Bush; Andrew Francis

doi:10.1016/S0006-3223(96)00378-2

Synergism of lorazepam and electroconvulsive therapy in the treatment of catatonia

Georgios Petrides
, Krishna M. Divadeenam
, George Bush
, Andrew Francis

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Electroconvulsive therapy (ECT) and lorazepam are effective treatments for catatonia. ECT combined with benzodiazepines has been associated with reduced efficacy and efficiency and therefore is not recommended in the routine practice of ECT. We report 5 prospectively identified cases of catatonia treated either sequentially or concurrently with lorazepam and ECT. In each case, the combination of lorazepam with ECT was superior to monotherapy. This apparent synergism, its possible mechanisms, and its implications for treating catatonia are discussed.

Original language	English (US)
Pages (from-to)	375-381
Number of pages	7
Journal	Biological Psychiatry
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/S0006-3223(96)00378-2
State	Published - Sep 1 1997

All Science Journal Classification (ASJC) codes

Biological Psychiatry

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10.1016/S0006-3223(96)00378-2

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abstract = "Electroconvulsive therapy (ECT) and lorazepam are effective treatments for catatonia. ECT combined with benzodiazepines has been associated with reduced efficacy and efficiency and therefore is not recommended in the routine practice of ECT. We report 5 prospectively identified cases of catatonia treated either sequentially or concurrently with lorazepam and ECT. In each case, the combination of lorazepam with ECT was superior to monotherapy. This apparent synergism, its possible mechanisms, and its implications for treating catatonia are discussed.",

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AU - Francis, Andrew

PY - 1997/9/1

Y1 - 1997/9/1

N2 - Electroconvulsive therapy (ECT) and lorazepam are effective treatments for catatonia. ECT combined with benzodiazepines has been associated with reduced efficacy and efficiency and therefore is not recommended in the routine practice of ECT. We report 5 prospectively identified cases of catatonia treated either sequentially or concurrently with lorazepam and ECT. In each case, the combination of lorazepam with ECT was superior to monotherapy. This apparent synergism, its possible mechanisms, and its implications for treating catatonia are discussed.

AB - Electroconvulsive therapy (ECT) and lorazepam are effective treatments for catatonia. ECT combined with benzodiazepines has been associated with reduced efficacy and efficiency and therefore is not recommended in the routine practice of ECT. We report 5 prospectively identified cases of catatonia treated either sequentially or concurrently with lorazepam and ECT. In each case, the combination of lorazepam with ECT was superior to monotherapy. This apparent synergism, its possible mechanisms, and its implications for treating catatonia are discussed.

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JO - Biological Psychiatry

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Synergism of lorazepam and electroconvulsive therapy in the treatment of catatonia

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