TY - JOUR
T1 - Synthes is and biological evaluation of novelspiro 6-methoxytetralin-1,30- pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice
AU - Hossain Sk, Ugir
AU - Sharma, Arun K.
AU - Ghosh, Sulekha
AU - Bhattacharya, Sudin
N1 - Funding Information:
This work is supported by grant from CSIR (I (1728)/02/EMR-II) & (9/30(032)/2003-EMR-I). Dr. Sk. gratefully acknowledges CSIR for Junior & Senior Research Fellowship. The authors wish to thank the Director, CNCI for the support in this study. We also thank Dr. Sukta Das for her helpful comments in the preparation of the manuscript.
PY - 2010/8
Y1 - 2010/8
N2 - A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium-(Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST),superoxide dismutase (SOD),catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities,e.g.,alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds,6d being the most active one (6d>6c>6b>6a).
AB - A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium-(Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST),superoxide dismutase (SOD),catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities,e.g.,alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds,6d being the most active one (6d>6c>6b>6a).
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U2 - 10.1016/j.ejmech.2010.04.001
DO - 10.1016/j.ejmech.2010.04.001
M3 - Article
C2 - 20457475
AN - SCOPUS:77954309517
SN - 0223-5234
VL - 45
SP - 3265
EP - 3273
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 8
ER -