Syntheses and structure-activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents

Bo Wang; Yang Liu; Yanshi Wang; Xin Liu; Mao Sheng Cheng

doi:10.1016/j.bmcl.2012.09.075

Syntheses and structure-activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents

Bo Wang, Yang Liu, Yanshi Wang, Xin Liu, Mao Sheng Cheng

Chemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds (5c and 5f) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them (5d, 5f and 5h) showed strong inhibition against HT1080.

Original language	English (US)
Pages (from-to)	7110-7113
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2012.09.075
State	Published - Dec 1 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2012.09.075

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abstract = "Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds (5c and 5f) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them (5d, 5f and 5h) showed strong inhibition against HT1080.",

author = "Bo Wang and Yang Liu and Yanshi Wang and Xin Liu and Cheng, {Mao Sheng}",

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AU - Wang, Bo

AU - Liu, Yang

AU - Wang, Yanshi

AU - Liu, Xin

AU - Cheng, Mao Sheng

PY - 2012/12/1

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AB - Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds (5c and 5f) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them (5d, 5f and 5h) showed strong inhibition against HT1080.

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Syntheses and structure-activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents

Abstract

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