Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

R. S. Pavelyev, R. R. Khairullina, S. A. Koshkin, A. G. Iksanova, O. A. Lodochnikova, N. N. Khaertdinov, G. F. Sitdikova, A. F. Safina, E. G. Aleksandrova, L. E. Ziganshina, Yu G. Shtyrlin

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Abstract

An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.

Original languageEnglish (US)
Pages (from-to)519-531
Number of pages13
JournalRussian Chemical Bulletin
Volume65
Issue number2
DOIs
StatePublished - Feb 1 2016

All Science Journal Classification (ASJC) codes

  • General Chemistry

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