Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

R. S. Pavelyev; R. R. Khairullina; S. A. Koshkin; A. G. Iksanova; O. A. Lodochnikova; N. N. Khaertdinov; G. F. Sitdikova; A. F. Safina; E. G. Aleksandrova; L. E. Ziganshina; Yu G. Shtyrlin

doi:10.1007/s11172-016-1332-0

Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

R. S. Pavelyev, R. R. Khairullina, S. A. Koshkin, A. G. Iksanova, O. A. Lodochnikova, N. N. Khaertdinov, G. F. Sitdikova, A. F. Safina, E. G. Aleksandrova, L. E. Ziganshina, Yu G. Shtyrlin

Huck Institutes of the Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.

Original language	English (US)
Pages (from-to)	519-531
Number of pages	13
Journal	Russian Chemical Bulletin
Volume	65
Issue number	2
DOIs	https://doi.org/10.1007/s11172-016-1332-0
State	Published - Feb 1 2016

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1007/s11172-016-1332-0

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Pavelyev, R. S., Khairullina, R. R., Koshkin, S. A., Iksanova, A. G., Lodochnikova, O. A., Khaertdinov, N. N., Sitdikova, G. F., Safina, A. F., Aleksandrova, E. G., Ziganshina, L. E., & Shtyrlin, Y. G. (2016). Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine. Russian Chemical Bulletin, 65(2), 519-531. https://doi.org/10.1007/s11172-016-1332-0

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title = "Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine",

abstract = "An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.",

author = "Pavelyev, {R. S.} and Khairullina, {R. R.} and Koshkin, {S. A.} and Iksanova, {A. G.} and Lodochnikova, {O. A.} and Khaertdinov, {N. N.} and Sitdikova, {G. F.} and Safina, {A. F.} and Aleksandrova, {E. G.} and Ziganshina, {L. E.} and Shtyrlin, {Yu G.}",

note = "Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",

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doi = "10.1007/s11172-016-1332-0",

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Pavelyev, RS, Khairullina, RR, Koshkin, SA, Iksanova, AG, Lodochnikova, OA, Khaertdinov, NN, Sitdikova, GF, Safina, AF, Aleksandrova, EG, Ziganshina, LE & Shtyrlin, YG 2016, 'Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine', Russian Chemical Bulletin, vol. 65, no. 2, pp. 519-531. https://doi.org/10.1007/s11172-016-1332-0

TY - JOUR

T1 - Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

AU - Pavelyev, R. S.

AU - Khairullina, R. R.

AU - Koshkin, S. A.

AU - Iksanova, A. G.

AU - Lodochnikova, O. A.

AU - Khaertdinov, N. N.

AU - Sitdikova, G. F.

AU - Safina, A. F.

AU - Aleksandrova, E. G.

AU - Ziganshina, L. E.

AU - Shtyrlin, Yu G.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.

AB - An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.

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U2 - 10.1007/s11172-016-1332-0

DO - 10.1007/s11172-016-1332-0

M3 - Article

AN - SCOPUS:85013808583

SN - 1066-5285

VL - 65

SP - 519

EP - 531

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

IS - 2

ER -

Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

Abstract

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