Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

R. S. Pavelyev; R. R. Khairullina; S. A. Koshkin; A. G. Iksanova; O. A. Lodochnikova; N. N. Khaertdinov; G. F. Sitdikova; A. F. Safina; E. G. Aleksandrova; L. E. Ziganshina; Yu G. Shtyrlin

doi:10.1007/s11172-016-1332-0

Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

R. S. Pavelyev
, R. R. Khairullina
, S. A. Koshkin
, A. G. Iksanova
, O. A. Lodochnikova
, N. N. Khaertdinov
, G. F. Sitdikova
, A. F. Safina
, E. G. Aleksandrova
, L. E. Ziganshina
, Yu G. Shtyrlin

Huck Institutes of the Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.

Original language	English (US)
Pages (from-to)	519-531
Number of pages	13
Journal	Russian Chemical Bulletin
Volume	65
Issue number	2
DOIs	https://doi.org/10.1007/s11172-016-1332-0
State	Published - Feb 1 2016

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1007/s11172-016-1332-0

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Pavelyev, R. S., Khairullina, R. R., Koshkin, S. A., Iksanova, A. G., Lodochnikova, O. A., Khaertdinov, N. N., Sitdikova, G. F., Safina, A. F., Aleksandrova, E. G., Ziganshina, L. E., & Shtyrlin, Y. G. (2016). Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine. Russian Chemical Bulletin, 65(2), 519-531. https://doi.org/10.1007/s11172-016-1332-0

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title = "Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine",

abstract = "An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.",

author = "Pavelyev, \{R. S.\} and Khairullina, \{R. R.\} and Koshkin, \{S. A.\} and Iksanova, \{A. G.\} and Lodochnikova, \{O. A.\} and Khaertdinov, \{N. N.\} and Sitdikova, \{G. F.\} and Safina, \{A. F.\} and Aleksandrova, \{E. G.\} and Ziganshina, \{L. E.\} and Shtyrlin, \{Yu G.\}",

note = "Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",

year = "2016",

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doi = "10.1007/s11172-016-1332-0",

language = "English (US)",

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Pavelyev, RS, Khairullina, RR, Koshkin, SA, Iksanova, AG, Lodochnikova, OA, Khaertdinov, NN, Sitdikova, GF, Safina, AF, Aleksandrova, EG, Ziganshina, LE & Shtyrlin, YG 2016, 'Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine', Russian Chemical Bulletin, vol. 65, no. 2, pp. 519-531. https://doi.org/10.1007/s11172-016-1332-0

TY - JOUR

T1 - Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

AU - Pavelyev, R. S.

AU - Khairullina, R. R.

AU - Koshkin, S. A.

AU - Iksanova, A. G.

AU - Lodochnikova, O. A.

AU - Khaertdinov, N. N.

AU - Sitdikova, G. F.

AU - Safina, A. F.

AU - Aleksandrova, E. G.

AU - Ziganshina, L. E.

AU - Shtyrlin, Yu G.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.

AB - An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.

UR - https://www.scopus.com/pages/publications/85013808583

UR - https://www.scopus.com/pages/publications/85013808583#tab=citedBy

U2 - 10.1007/s11172-016-1332-0

DO - 10.1007/s11172-016-1332-0

M3 - Article

AN - SCOPUS:85013808583

SN - 1066-5285

VL - 65

SP - 519

EP - 531

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

IS - 2

ER -

Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

Abstract

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