Synthesis and antiviral activities of 3-deaza-3-fluoroaristeromycin and its 5′ analogues

Qi Chen; Chong Liu; Gloria Komazin; Terry L. Bowlin; Stewart W. Schneller

doi:10.1016/j.bmc.2014.10.014

Synthesis and antiviral activities of 3-deaza-3-fluoroaristeromycin and its 5′ analogues

Qi Chen, Chong Liu, Gloria Komazin, Terry L. Bowlin, Stewart W. Schneller

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The naturally occurring adenine based carbocyclic nucleosides aristeromycin and neplanocin A and their 3-deaza analogues have found a prominent place in the search for diverse antiviral activity agent scaffolds because of their ability to inhibit S-adenosylhomocysteine (AdoHcy) hydrolase. Following the lead of these compounds, their 3-deaza-3-fluoroaristeromycin analogues have been synthesized and their effect on S-adenosylhomocysteine hydrolase and RNA and DNA viruses determined.

Original language	English (US)
Pages (from-to)	6961-6964
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	22
Issue number	24
DOIs	https://doi.org/10.1016/j.bmc.2014.10.014
State	Published - Dec 15 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2014.10.014

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abstract = "The naturally occurring adenine based carbocyclic nucleosides aristeromycin and neplanocin A and their 3-deaza analogues have found a prominent place in the search for diverse antiviral activity agent scaffolds because of their ability to inhibit S-adenosylhomocysteine (AdoHcy) hydrolase. Following the lead of these compounds, their 3-deaza-3-fluoroaristeromycin analogues have been synthesized and their effect on S-adenosylhomocysteine hydrolase and RNA and DNA viruses determined.",

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AU - Bowlin, Terry L.

AU - Schneller, Stewart W.

PY - 2014/12/15

Y1 - 2014/12/15

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AB - The naturally occurring adenine based carbocyclic nucleosides aristeromycin and neplanocin A and their 3-deaza analogues have found a prominent place in the search for diverse antiviral activity agent scaffolds because of their ability to inhibit S-adenosylhomocysteine (AdoHcy) hydrolase. Following the lead of these compounds, their 3-deaza-3-fluoroaristeromycin analogues have been synthesized and their effect on S-adenosylhomocysteine hydrolase and RNA and DNA viruses determined.

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Synthesis and antiviral activities of 3-deaza-3-fluoroaristeromycin and its 5′ analogues

Abstract

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