TY - JOUR
T1 - Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se′-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)-against colon cancer
AU - Desai, Dhimant
AU - Madhunapantula, Subba Rao V.
AU - Gowdahalli, Krishnegowda
AU - Sharma, Arati
AU - Chandagaludoreswamy, Raghavendragowda
AU - El-Bayoumy, Karam
AU - Robertson, Gavin P.
AU - Amin, Shantu
N1 - Funding Information:
The authors would like to thank Dr. Jyh-Ming Lin from the Penn State Hershey Cancer Institute Instrumentation Facility for NMR spectra and Jenny Dai for performing the MS analysis. This study was supported by NIH R03 CA1378763 (D.D.), NCI contract NCI-CB-56603 (S.A.), and funds from Penn State Cancer Institute.
PY - 2010/3/15
Y1 - 2010/3/15
N2 - Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.
AB - Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.
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U2 - 10.1016/j.bmcl.2009.09.071
DO - 10.1016/j.bmcl.2009.09.071
M3 - Article
C2 - 20153642
AN - SCOPUS:77549085001
SN - 0960-894X
VL - 20
SP - 2038
EP - 2043
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 6
ER -