Synthesis of α-hydroxy(polyprenyl) bisphosphonates

O. O. Kolodyazhnaya, O. I. Kolodyazhnyi, R. A. Cherkasov, A. R. Garifzyanov, N. V. Davletshina, S. A. Koshkin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Bisphosphonates derived from natural terpenes were synthesized by phosphonylation of corresponding aldehydes. The general strategy of introduction of the phosphonate groups into the polyprenol molecule involves successive treatment of a hydroxyl compound by Swern reagent to oxidize the C-OH group into C=O and a (EtO)3P/[PyH]+ClO - 4 mixture to phosphylate the resulting carbonyl compound.

Original languageEnglish (US)
Pages (from-to)647-653
Number of pages7
JournalRussian Journal of General Chemistry
Issue number4
StatePublished - Apr 2014

All Science Journal Classification (ASJC) codes

  • General Chemistry


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