TY - JOUR
T1 - Synthesis of 1,2-benzisoxazole 2-oxides
AU - Kociolek, Martin George
AU - Hoermann, Olivia
PY - 2012/9/1
Y1 - 2012/9/1
N2 - (Chemical Equation Presented) A series of 2-hydroxyaryl ketoximes were converted to the corresponding 1,2- benzisoxazole 2-oxides by treatment with iodobenzene diacetate (in acetic acid or methanol) or N-chlorosuccinimide in water. Both methods gave moderate to excellent yields for a variety of substituted oximes under mild conditions within short reaction times. The latter method has the advantages of an aqueous solvent and lack of halogenated organic by-products.
AB - (Chemical Equation Presented) A series of 2-hydroxyaryl ketoximes were converted to the corresponding 1,2- benzisoxazole 2-oxides by treatment with iodobenzene diacetate (in acetic acid or methanol) or N-chlorosuccinimide in water. Both methods gave moderate to excellent yields for a variety of substituted oximes under mild conditions within short reaction times. The latter method has the advantages of an aqueous solvent and lack of halogenated organic by-products.
UR - http://www.scopus.com/inward/record.url?scp=84861980387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861980387&partnerID=8YFLogxK
U2 - 10.1080/00397911.2011.563451
DO - 10.1080/00397911.2011.563451
M3 - Article
AN - SCOPUS:84861980387
SN - 0039-7911
VL - 42
SP - 2632
EP - 2638
JO - Synthetic Communications
JF - Synthetic Communications
IS - 17
ER -