Synthesis of a heparinized poly(organophosphazene)

Thomas X. Neenan; Harry R. Allcock

doi:10.1016/0142-9612(82)90037-0

Synthesis of a heparinized poly(organophosphazene)

Thomas X. Neenan, Harry R. Allcock

Research output: Contribution to journal › Article › peer-review

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Abstract

The synthesis of a new potential anti-thrombogenic polymer is described. Limited halogenation of an aryloxysubstituted polyphosphazene, followed by quaternization with triethylamine yielded a polymer capable of forming polyelectrolyte complexes with sodium heparin. The results of preliminary clotting tests with bovine blood are presented.

Original language	English (US)
Pages (from-to)	78-80
Number of pages	3
Journal	Biomaterials
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0142-9612(82)90037-0
State	Published - Apr 1982

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/0142-9612(82)90037-0

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title = "Synthesis of a heparinized poly(organophosphazene)",

abstract = "The synthesis of a new potential anti-thrombogenic polymer is described. Limited halogenation of an aryloxysubstituted polyphosphazene, followed by quaternization with triethylamine yielded a polymer capable of forming polyelectrolyte complexes with sodium heparin. The results of preliminary clotting tests with bovine blood are presented.",

author = "Neenan, {Thomas X.} and Allcock, {Harry R.}",

note = "Funding Information: This work was supported by the National Institutes of Health through grant no. 5 ROI HL 11418 from the National Heart, Lung and Blood Institute.",

year = "1982",

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T1 - Synthesis of a heparinized poly(organophosphazene)

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AU - Allcock, Harry R.

N1 - Funding Information: This work was supported by the National Institutes of Health through grant no. 5 ROI HL 11418 from the National Heart, Lung and Blood Institute.

PY - 1982/4

Y1 - 1982/4

N2 - The synthesis of a new potential anti-thrombogenic polymer is described. Limited halogenation of an aryloxysubstituted polyphosphazene, followed by quaternization with triethylamine yielded a polymer capable of forming polyelectrolyte complexes with sodium heparin. The results of preliminary clotting tests with bovine blood are presented.

AB - The synthesis of a new potential anti-thrombogenic polymer is described. Limited halogenation of an aryloxysubstituted polyphosphazene, followed by quaternization with triethylamine yielded a polymer capable of forming polyelectrolyte complexes with sodium heparin. The results of preliminary clotting tests with bovine blood are presented.

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U2 - 10.1016/0142-9612(82)90037-0

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JO - Biomaterials

JF - Biomaterials

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ER -

Synthesis of a heparinized poly(organophosphazene)

Abstract

All Science Journal Classification (ASJC) codes

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