Synthesis of a tetrasaccharide substrate of heparanase

Jianfang Chen; Ying Zhou; Chen Chen; Weichang Xu; Biao Yu

doi:10.1016/j.carres.2008.06.011

Synthesis of a tetrasaccharide substrate of heparanase

Jianfang Chen
, Ying Zhou
, Chen Chen
, Weichang Xu
, Biao Yu

Chemistry

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely β-d-GlcA(2S)-(1→4)-α-d-GlcN(NS,6S)-(1→4)-β-d-GlcA-(1→4)-α-d-GlcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step.

Original language	English (US)
Pages (from-to)	2853-2862
Number of pages	10
Journal	Carbohydrate Research
Volume	343
Issue number	17
DOIs	https://doi.org/10.1016/j.carres.2008.06.011
State	Published - Nov 24 2008

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/j.carres.2008.06.011

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title = "Synthesis of a tetrasaccharide substrate of heparanase",

abstract = "A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely β-d-GlcA(2S)-(1→4)-α-d-GlcN(NS,6S)-(1→4)-β-d-GlcA-(1→4)-α-d-GlcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step.",

author = "Jianfang Chen and Ying Zhou and Chen Chen and Weichang Xu and Biao Yu",

year = "2008",

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doi = "10.1016/j.carres.2008.06.011",

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journal = "Carbohydrate Research",

issn = "0008-6215",

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T1 - Synthesis of a tetrasaccharide substrate of heparanase

AU - Chen, Jianfang

AU - Zhou, Ying

AU - Chen, Chen

AU - Xu, Weichang

AU - Yu, Biao

PY - 2008/11/24

Y1 - 2008/11/24

N2 - A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely β-d-GlcA(2S)-(1→4)-α-d-GlcN(NS,6S)-(1→4)-β-d-GlcA-(1→4)-α-d-GlcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step.

AB - A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely β-d-GlcA(2S)-(1→4)-α-d-GlcN(NS,6S)-(1→4)-β-d-GlcA-(1→4)-α-d-GlcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step.

UR - https://www.scopus.com/pages/publications/53849127830

UR - https://www.scopus.com/pages/publications/53849127830#tab=citedBy

U2 - 10.1016/j.carres.2008.06.011

DO - 10.1016/j.carres.2008.06.011

M3 - Article

C2 - 18619582

AN - SCOPUS:53849127830

SN - 0008-6215

VL - 343

SP - 2853

EP - 2862

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 17

ER -

Synthesis of a tetrasaccharide substrate of heparanase

Abstract

All Science Journal Classification (ASJC) codes

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