Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus

Dipanjan Pan; Shelton D. Caruthers; Angana Senpan; Ceren Yalaz; Allen J. Stacy; Grace Hu; Jon N. Marsh; Patrick J. Gaffney; Samuel A. Wickline; Gregory M. Lanza

doi:10.1021/ja201918u

Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus

Dipanjan Pan, Shelton D. Caruthers, Angana Senpan, Ceren Yalaz, Allen J. Stacy, Grace Hu, Jon N. Marsh, Patrick J. Gaffney, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

Original language	English (US)
Pages (from-to)	9168-9171
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	24
DOIs	https://doi.org/10.1021/ja201918u
State	Published - Jun 22 2011

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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Pan, D., Caruthers, S. D., Senpan, A., Yalaz, C., Stacy, A. J., Hu, G., Marsh, J. N., Gaffney, P. J., Wickline, S. A., & Lanza, G. M. (2011). Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus. Journal of the American Chemical Society, 133(24), 9168-9171. https://doi.org/10.1021/ja201918u

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abstract = "A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.",

author = "Dipanjan Pan and Caruthers, \{Shelton D.\} and Angana Senpan and Ceren Yalaz and Stacy, \{Allen J.\} and Grace Hu and Marsh, \{Jon N.\} and Gaffney, \{Patrick J.\} and Wickline, \{Samuel A.\} and Lanza, \{Gregory M.\}",

year = "2011",

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doi = "10.1021/ja201918u",

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AU - Pan, Dipanjan

AU - Caruthers, Shelton D.

AU - Senpan, Angana

AU - Yalaz, Ceren

AU - Stacy, Allen J.

AU - Hu, Grace

AU - Marsh, Jon N.

AU - Gaffney, Patrick J.

AU - Wickline, Samuel A.

AU - Lanza, Gregory M.

PY - 2011/6/22

Y1 - 2011/6/22

N2 - A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

AB - A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

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JF - Journal of the American Chemical Society

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ER -

Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus

Abstract

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