Synthesis of Poly [(amino acid alkyl ester)phosphazenes]1~3

Phosphazene high polymers with glycino ethyl ester, leucino methyl ester, alanino methyl ester, and phenyl alanino methyl ester substituents have been synthesized by the interaction of poly(dichlorophosphazene) (IV) with amino acid esters. Total halogen replacement was achieved only with glycine ethyl ester, but replacement of the remaining chlorine could be effected by the subsequent introduction of methylamino groups as cosubstituents. In aqueous media the polymers were susceptible to a slow hydrolytic decomposition. In addition, a spontaneous chain cleavage process was detected that involved reactions of the substituent groups. All the polymers were basic and bound hydrogen chloride strongly. The physical properties and biomedical potentialities of the polymers are also discussed.