TY - GEN
T1 - Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions
AU - Chinnasami, Harish
AU - Hayes, Daniel J.
AU - Devireddy, Ram
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Poly (l-lactic acid) (PLLA) scaffolds for bone grafts were prepared by using Thermally Induced Phase Separation (TIPS) method. Solutions of PLLA-dioxane was formed by dissolving a predetermined value of PLLA in dioxane (3, 7 and 10% wt/vol) at 323K. These solutions were frozen at controlled cooling rates (1, 10 and 40°C/min) in cylindrical capsules. The frozen solutions were freeze-dried for a period of 48 hours for the frozen dioxane to completely sublimate, leaving the porous PLLA scaffold. The scaffolds which were formed under different processing conditions were characterized in terms of porosity, pore sizes and compressive moduli.
AB - Poly (l-lactic acid) (PLLA) scaffolds for bone grafts were prepared by using Thermally Induced Phase Separation (TIPS) method. Solutions of PLLA-dioxane was formed by dissolving a predetermined value of PLLA in dioxane (3, 7 and 10% wt/vol) at 323K. These solutions were frozen at controlled cooling rates (1, 10 and 40°C/min) in cylindrical capsules. The frozen solutions were freeze-dried for a period of 48 hours for the frozen dioxane to completely sublimate, leaving the porous PLLA scaffold. The scaffolds which were formed under different processing conditions were characterized in terms of porosity, pore sizes and compressive moduli.
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U2 - 10.1115/SBC2013-14168
DO - 10.1115/SBC2013-14168
M3 - Conference contribution
AN - SCOPUS:84894677278
SN - 9780791855607
T3 - ASME 2013 Summer Bioengineering Conference, SBC 2013
BT - ASME 2013 Summer Bioengineering Conference, SBC 2013
T2 - ASME 2013 Summer Bioengineering Conference, SBC 2013
Y2 - 26 June 2013 through 29 June 2013
ER -