Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38

James R. Henry; John H. Dodd

doi:10.1016/S0040-4039(98)01991-1

Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38

James R. Henry, John H. Dodd

Chemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The regiospecific synthesis of RWJ 68354, a potent inhibitor of the p38 MAP kinase, via a variation of the Bischler-Mohlau indole synthesis is reported.

Original language	English (US)
Pages (from-to)	8763-8764
Number of pages	2
Journal	Tetrahedron Letters
Volume	39
Issue number	48
DOIs	https://doi.org/10.1016/S0040-4039(98)01991-1
State	Published - Nov 26 1998

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)01991-1

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title = "Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38",

abstract = "The regiospecific synthesis of RWJ 68354, a potent inhibitor of the p38 MAP kinase, via a variation of the Bischler-Mohlau indole synthesis is reported.",

author = "Henry, {James R.} and Dodd, {John H.}",

year = "1998",

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doi = "10.1016/S0040-4039(98)01991-1",

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T1 - Synthesis of RWJ 68354

T2 - A potent inhibitor of the MAP kinase p38

AU - Henry, James R.

AU - Dodd, John H.

PY - 1998/11/26

Y1 - 1998/11/26

N2 - The regiospecific synthesis of RWJ 68354, a potent inhibitor of the p38 MAP kinase, via a variation of the Bischler-Mohlau indole synthesis is reported.

AB - The regiospecific synthesis of RWJ 68354, a potent inhibitor of the p38 MAP kinase, via a variation of the Bischler-Mohlau indole synthesis is reported.

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U2 - 10.1016/S0040-4039(98)01991-1

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 48

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Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38

Abstract

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