Synthesis of sheet-coil-helix and coil-sheet-helix triblock copolymers by combining ROMP with palladium-mediated isocyanide polymerization

Scott K. Pomarico; Diane S. Lye; Elizabeth Elacqua; Marcus Weck

doi:10.1039/c8py01361f

Synthesis of sheet-coil-helix and coil-sheet-helix triblock copolymers by combining ROMP with palladium-mediated isocyanide polymerization

Scott K. Pomarico, Diane S. Lye, Elizabeth Elacqua, Marcus Weck

Chemistry

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We report a synthetic route to construct architecturally well-defined triblock copolymers, in particular copolymers featuring secondary structures that form sheet-coil-helix and coil-sheet-helix motifs, through a macroinitiation strategy that combines sequential ring-opening metathesis polymerization (ROMP) with palladium-mediated isocyanide polymerization. Throughout the triblock copolymer fabrication, the individual blocks retained their secondary structures as evidenced by circular dicroism (CD) and fluorescence spectroscopies. Our strategy introduces a facile way to create complex ABC triblock copolymers that contain architecturally-diverse backbones, whilst retaining the ability to control sequence: sheet-coil-helix or coil-sheet-helix.

Original language	English (US)
Pages (from-to)	5655-5659
Number of pages	5
Journal	Polymer Chemistry
Volume	9
Issue number	48
DOIs	https://doi.org/10.1039/c8py01361f
State	Published - Dec 28 2018

All Science Journal Classification (ASJC) codes

Bioengineering
Biochemistry
Polymers and Plastics
Organic Chemistry

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10.1039/c8py01361f

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title = "Synthesis of sheet-coil-helix and coil-sheet-helix triblock copolymers by combining ROMP with palladium-mediated isocyanide polymerization",

abstract = "We report a synthetic route to construct architecturally well-defined triblock copolymers, in particular copolymers featuring secondary structures that form sheet-coil-helix and coil-sheet-helix motifs, through a macroinitiation strategy that combines sequential ring-opening metathesis polymerization (ROMP) with palladium-mediated isocyanide polymerization. Throughout the triblock copolymer fabrication, the individual blocks retained their secondary structures as evidenced by circular dicroism (CD) and fluorescence spectroscopies. Our strategy introduces a facile way to create complex ABC triblock copolymers that contain architecturally-diverse backbones, whilst retaining the ability to control sequence: sheet-coil-helix or coil-sheet-helix.",

author = "Pomarico, \{Scott K.\} and Lye, \{Diane S.\} and Elizabeth Elacqua and Marcus Weck",

note = "Funding Information: The authors acknowledge financial support from the National Science Foundation under award number CHE-1506890. We also acknowledge the National Institutes of Health for the purchase of the Advance III-600 CPTCI-cryoprobe head (S10 grant, OD016343) and New York University for the purchase of the Circular Dichroism Spectropolarimeter. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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doi = "10.1039/c8py01361f",

language = "English (US)",

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journal = "Polymer Chemistry",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Synthesis of sheet-coil-helix and coil-sheet-helix triblock copolymers by combining ROMP with palladium-mediated isocyanide polymerization

AU - Pomarico, Scott K.

AU - Lye, Diane S.

AU - Elacqua, Elizabeth

AU - Weck, Marcus

N1 - Funding Information: The authors acknowledge financial support from the National Science Foundation under award number CHE-1506890. We also acknowledge the National Institutes of Health for the purchase of the Advance III-600 CPTCI-cryoprobe head (S10 grant, OD016343) and New York University for the purchase of the Circular Dichroism Spectropolarimeter. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018/12/28

Y1 - 2018/12/28

N2 - We report a synthetic route to construct architecturally well-defined triblock copolymers, in particular copolymers featuring secondary structures that form sheet-coil-helix and coil-sheet-helix motifs, through a macroinitiation strategy that combines sequential ring-opening metathesis polymerization (ROMP) with palladium-mediated isocyanide polymerization. Throughout the triblock copolymer fabrication, the individual blocks retained their secondary structures as evidenced by circular dicroism (CD) and fluorescence spectroscopies. Our strategy introduces a facile way to create complex ABC triblock copolymers that contain architecturally-diverse backbones, whilst retaining the ability to control sequence: sheet-coil-helix or coil-sheet-helix.

AB - We report a synthetic route to construct architecturally well-defined triblock copolymers, in particular copolymers featuring secondary structures that form sheet-coil-helix and coil-sheet-helix motifs, through a macroinitiation strategy that combines sequential ring-opening metathesis polymerization (ROMP) with palladium-mediated isocyanide polymerization. Throughout the triblock copolymer fabrication, the individual blocks retained their secondary structures as evidenced by circular dicroism (CD) and fluorescence spectroscopies. Our strategy introduces a facile way to create complex ABC triblock copolymers that contain architecturally-diverse backbones, whilst retaining the ability to control sequence: sheet-coil-helix or coil-sheet-helix.

UR - https://www.scopus.com/pages/publications/85058495870

UR - https://www.scopus.com/inward/citedby.url?scp=85058495870&partnerID=8YFLogxK

U2 - 10.1039/c8py01361f

DO - 10.1039/c8py01361f

M3 - Article

AN - SCOPUS:85058495870

SN - 1759-9954

VL - 9

SP - 5655

EP - 5659

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 48

ER -

Synthesis of sheet-coil-helix and coil-sheet-helix triblock copolymers by combining ROMP with palladium-mediated isocyanide polymerization

Abstract

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