Synthesis of the tetracyclic skeleton of the lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence

Pradeep S. Chauhan; Joshua R. Sacher; Steven M. Weinreb

doi:10.1021/ol503571a

Synthesis of the tetracyclic skeleton of the lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence

Pradeep S. Chauhan
, Joshua R. Sacher
, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A synthesis of the complete tetracyclic framework of the structurally unique Lycopodium alkaloid lycopladine H has been accomplished using a strategy involving a double alkene hydroformylation/intramolecular reductive amination to form the azocane and spiro-piperidine moieties of the natural product.

Original language	English (US)
Pages (from-to)	806-808
Number of pages	3
Journal	Organic Letters
Volume	17
Issue number	4
DOIs	https://doi.org/10.1021/ol503571a
State	Published - Feb 20 2015

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol503571a

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abstract = "A synthesis of the complete tetracyclic framework of the structurally unique Lycopodium alkaloid lycopladine H has been accomplished using a strategy involving a double alkene hydroformylation/intramolecular reductive amination to form the azocane and spiro-piperidine moieties of the natural product.",

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AU - Sacher, Joshua R.

AU - Weinreb, Steven M.

PY - 2015/2/20

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AB - A synthesis of the complete tetracyclic framework of the structurally unique Lycopodium alkaloid lycopladine H has been accomplished using a strategy involving a double alkene hydroformylation/intramolecular reductive amination to form the azocane and spiro-piperidine moieties of the natural product.

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U2 - 10.1021/ol503571a

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JO - Organic Letters

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Synthesis of the tetracyclic skeleton of the lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence

Abstract

All Science Journal Classification (ASJC) codes

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