TY - JOUR
T1 - Systematic review of hypofractionated radiation therapy for prostate cancer
AU - Zaorsky, Nicholas G.
AU - Ohri, Nitin
AU - Showalter, Timothy N.
AU - Dicker, Adam P.
AU - Den, Robert B.
PY - 2013/11
Y1 - 2013/11
N2 - Prostate cancer is the second most prevalent solid tumor diagnosed in men in the United States and Western Europe. Conventionally fractionated external beam radiation therapy (1.8-2.0. Gy/fraction) is an established treatment modality for men in all disease risk groups. Emerging evidence from experimental and clinical studies suggests that the α/β ratio for prostate cancer may be as low as 1.5. Gy, which has prompted investigators around the world to explore moderately hypofractionated radiation therapy (2.1-3.5. Gy/fraction). We review the impetus behind moderate hypofractionation and the current clinical evidence supporting moderate hypofractionated radiation therapy for prostate cancer. Although hypofractionated radiation therapy has many theoretical advantages, there is no clear evidence from prospective, randomized, controlled trials showing that hypofractionated schedules have improved outcomes or lower toxicity than conventionally fractionated regimens. Currently, hypofractionated schedules should only be used in the context of clinical trials. High dose rate brachytherapy and stereotactic body radiation therapy (fraction size 3.5. Gy and greater) are alternative approaches to hypofractionation, but are beyond the scope of this report.
AB - Prostate cancer is the second most prevalent solid tumor diagnosed in men in the United States and Western Europe. Conventionally fractionated external beam radiation therapy (1.8-2.0. Gy/fraction) is an established treatment modality for men in all disease risk groups. Emerging evidence from experimental and clinical studies suggests that the α/β ratio for prostate cancer may be as low as 1.5. Gy, which has prompted investigators around the world to explore moderately hypofractionated radiation therapy (2.1-3.5. Gy/fraction). We review the impetus behind moderate hypofractionation and the current clinical evidence supporting moderate hypofractionated radiation therapy for prostate cancer. Although hypofractionated radiation therapy has many theoretical advantages, there is no clear evidence from prospective, randomized, controlled trials showing that hypofractionated schedules have improved outcomes or lower toxicity than conventionally fractionated regimens. Currently, hypofractionated schedules should only be used in the context of clinical trials. High dose rate brachytherapy and stereotactic body radiation therapy (fraction size 3.5. Gy and greater) are alternative approaches to hypofractionation, but are beyond the scope of this report.
UR - http://www.scopus.com/inward/record.url?scp=84881557290&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881557290&partnerID=8YFLogxK
U2 - 10.1016/j.ctrv.2013.01.008
DO - 10.1016/j.ctrv.2013.01.008
M3 - Review article
C2 - 23453861
AN - SCOPUS:84881557290
SN - 0305-7372
VL - 39
SP - 728
EP - 736
JO - Cancer Treatment Reviews
JF - Cancer Treatment Reviews
IS - 7
ER -