Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis

Barbara Kronsteiner, Josep Bassaganya-Riera, Casandra Philipson, Monica Viladomiu, Adria Carbo, Vida Abedi, Raquel Hontecillas

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Helicobacter pylori is the dominant member of the gastric microbiota in over half of the human population of which 5–15% develop gastritis or gastric malignancies. Immune responses to H. pylori are characterized by mixed T helper cell, cytotoxic T cell and NK cell responses. The presence of Tregs is essential for the control of gastritis and together with regulatory CX3CR1+ mononuclear phagocytes and immune-evasion strategies they enable life-long persistence of H. pylori. This H. pylori-induced regulatory environment might contribute to its cross-protective effect in inflammatory bowel disease and obesity. Here we review host-microbe interactions, the development of pro- and anti-inflammatory immune responses and how the latter contribute to H. pylori's role as beneficial member of the gut microbiota. Furthermore, we present the integration of existing and new data into a computational/mathematical model and its use for the investigation of immunological mechanisms underlying initiation, progression and outcomes of H. pylori infection.

Original languageEnglish (US)
Pages (from-to)3-21
Number of pages19
JournalGut microbes
Volume7
Issue number1
DOIs
StatePublished - Jan 2 2016

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Gastroenterology
  • Infectious Diseases
  • Microbiology

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