@article{b46c3f3bc5d34f9db61f59fe17ea8061,
title = "Systolic blood pressure control among individuals with type 2 diabetes: A comparative effectiveness analysis of three interventions",
abstract = "BACKGROUND The relative effectiveness of 3 approaches to blood pressure control- (i) an intensive lifestyle intervention (ILI) focused on weight loss, (ii) frequent goal-based monitoring of blood pressure with pharmacological management, and (iii) education and support-has not been established among overweight and obese adults with type 2 diabetes who are appropriate for each intervention. METHODS Participants from the Action for Health in Diabetes (Look AHEAD) and the Action to Control Cardiovascular Risk in Diabetes (ACCORD) cohorts who met criteria for both clinical trials were identified. The proportions of these individuals with systolic blood pressure (SBP) <140 mm Hg from annual standardized assessments over time were compared with generalized estimating equations. RESULTS Across 4 years among 480 Look AHEAD and 1,129 ACCORD participants with baseline SBPs between 130 and 159 mm Hg, ILI (OR = 1.46; 95% CI = [1.18-1.81]) and frequent goal-based monitoring with pharmacotherapy (OR = 1.51; 95% CI = [1.16-1.97]) yielded higher rates of blood pressure control compared to education and support. The intensive behavioral-based intervention may have been more effective among individuals with body mass index >30 kg/m2, while frequent goal-based monitoring with medication management may be more effective among individuals with lower body mass index (interaction P = 0.047). CONCLUSIONS Among overweight and obese adults with type 2 diabetes, both ILI and frequent goal-based monitoring with pharmacological management can be successful strategies for blood pressure control. clinical trials registry clinicaltrials.gov identifiers NCT00017953 (Look AHEAD) and NCT00000620 (ACCORD).",
author = "{Look AHEAD Research Group} and {ACCORD Study Group} and Espeland, {Mark A.} and Jeffery Probstfield and Donald Hire and Redmon, {J. B.} and Evans, {Gregory W.} and Mace Coday and Lewis, {Cora E.} and Johnson, {Karen C.} and Sharon Wilmoth and Judy Bahnson and Dulin, {Michael F.} and Green, {Jennifer B.} and Knowler, {William C.} and Abbas Kitabchi and Murillo, {Anne L.} and Kwame Osei and Rehman, {Shakaib U.} and Brancati, {Frederick L.} and Lee Swartz and Lawrence Cheskin and Clark, {Jeanne M.} and Kerry Stewart and Richard Rubin and Jean Arceci and Suzanne Ball and Jeanne Charleston and Danielle Diggins and Mia Johnson and Joyce Lambert and Kathy Michalski and Dawn Jiggetts and Chanchai Sapun and Bray, {George A.} and Kristi Rau and Allison Strate and Greenway, {Frank L.} and Ryan, {Donna H.} and Donald Williamson and Brandi Armand and Jennifer Arceneaux and Amy Bachand and Michelle Begnaud and Betsy Berhard and Elizabeth Caderette and Barbara Cerniauskas and David Creel and Diane Crow and Crystal Duncan and Helen Guay and W. Hwang",
note = "Funding Information: This work was supported by National Heart Lung and Blood Institute contracts N01-HC-95178, N01-HC-95179, N01-HC-95180, N01-HC-95181, N01-HC-95182, N01-HC-95183, N01-HC-95184, and IAA #Y1-HC-9035 and IAA#Y1-HC-1010. Other components of the National Institutes of Health, including the National Institute of, Diabetes and Digestive and Kidney Diseases, the National Institute on Aging, and the National Eye Institute, contributed funding. The Center for Disease Control funded, substudies within ACCORD on cost-effectiveness and health-related quality of life. General Clinical Research Centers provide support at many sites. Publisher Copyright: {\textcopyright} American Journal of Hypertension, Ltd 2015. All rights reserved.",
year = "2015",
month = may,
day = "11",
doi = "10.1093/ajh/hpu292",
language = "English (US)",
volume = "28",
pages = "995--1009",
journal = "American journal of hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "8",
}