T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis

Heather Rogers; Li Wang; Xiaobing Yu; Mawadda Alnaeeli; Kairong Cui; Keji Zhao; James J. Bieker; Josef Prchal; Suming Huang; Babette Weksler; Constance Tom Noguchi

doi:10.1074/jbc.M112.378398

T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis

Heather Rogers, Li Wang, Xiaobing Yu, Mawadda Alnaeeli, Kairong Cui, Keji Zhao, James J. Bieker, Josef Prchal, Suming Huang, Babette Weksler, Constance Tom Noguchi

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.

Original language	English (US)
Pages (from-to)	36720-36731
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.378398
State	Published - Oct 26 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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title = "T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis",

abstract = "Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.",

author = "Heather Rogers and Li Wang and Xiaobing Yu and Mawadda Alnaeeli and Kairong Cui and Keji Zhao and Bieker, {James J.} and Josef Prchal and Suming Huang and Babette Weksler and Noguchi, {Constance Tom}",

year = "2012",

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doi = "10.1074/jbc.M112.378398",

language = "English (US)",

volume = "287",

pages = "36720--36731",

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TY - JOUR

T1 - T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis

AU - Rogers, Heather

AU - Wang, Li

AU - Yu, Xiaobing

AU - Alnaeeli, Mawadda

AU - Cui, Kairong

AU - Zhao, Keji

AU - Bieker, James J.

AU - Prchal, Josef

AU - Huang, Suming

AU - Weksler, Babette

AU - Noguchi, Constance Tom

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.

AB - Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.

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JF - Journal of Biological Chemistry

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ER -

T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis

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