Abstract
Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.
Original language | English (US) |
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Pages (from-to) | 36720-36731 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 287 |
Issue number | 44 |
DOIs | |
State | Published - Oct 26 2012 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology