Abstract
Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 36720-36731 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 287 |
| Issue number | 44 |
| DOIs | |
| State | Published - Oct 26 2012 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
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