TY - JOUR
T1 - Tamoxifen Withdrawal Response
T2 - Report of a Case
AU - Belani, Chandra P.
AU - Pearl, Paula
AU - Whitley, Nancy O.
AU - Aisner, Joseph
PY - 1989/2
Y1 - 1989/2
N2 - A postmenopausal patient with breast cancer with a left infrahilar lung mass was treated with tamoxifen. She became asymptomatic, but after having stable disease for eight months, she developed progressive increase in the size of the mass necessitating tamoxifen withdrawal. Complete resolution of the mass occurred following withdrawal of tamoxifen. Withdrawal responses, though known to occur with additive hormonal treatment, especially complete regression of metastatic disease as seen in our patient, is not widely recognized. Thus, when clinically possible, patients should be observed off treatment for up to six weeks, before initiating a new therapeutic modality.
AB - A postmenopausal patient with breast cancer with a left infrahilar lung mass was treated with tamoxifen. She became asymptomatic, but after having stable disease for eight months, she developed progressive increase in the size of the mass necessitating tamoxifen withdrawal. Complete resolution of the mass occurred following withdrawal of tamoxifen. Withdrawal responses, though known to occur with additive hormonal treatment, especially complete regression of metastatic disease as seen in our patient, is not widely recognized. Thus, when clinically possible, patients should be observed off treatment for up to six weeks, before initiating a new therapeutic modality.
UR - http://www.scopus.com/inward/record.url?scp=0024535453&partnerID=8YFLogxK
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U2 - 10.1001/archinte.1989.00390020139030
DO - 10.1001/archinte.1989.00390020139030
M3 - Article
C2 - 2537066
AN - SCOPUS:0024535453
SN - 0003-9926
VL - 149
SP - 449
EP - 450
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 2
ER -
