TY - JOUR
T1 - Tamoxifen‐induced remission in breast cancer by escalating the dose to 40 mg daily after progression on 20 mg daily
T2 - A case report and review of the literature
AU - Manni, Andrea
AU - Arafah, Baha'uddin M.
PY - 1981/8/15
Y1 - 1981/8/15
N2 - An 80‐year‐old woman with metastatic breast cancer to the lungs and bones was treated with tamoxifen, 10 mg twice daily, with arrest of disease of six month's duration. At the time of progression, increasing the dosage to 20 mg twice daily resulted in an objective remission now lasting 8+ months. This finding indicates that in this patient, the taxoxifen dosage of 40 mg/daily had a significantly higher anti‐tumor effect than 20 mg/daily. Pertinent literature on the correlation of response with tamoxifen dosage is reviewed.
AB - An 80‐year‐old woman with metastatic breast cancer to the lungs and bones was treated with tamoxifen, 10 mg twice daily, with arrest of disease of six month's duration. At the time of progression, increasing the dosage to 20 mg twice daily resulted in an objective remission now lasting 8+ months. This finding indicates that in this patient, the taxoxifen dosage of 40 mg/daily had a significantly higher anti‐tumor effect than 20 mg/daily. Pertinent literature on the correlation of response with tamoxifen dosage is reviewed.
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U2 - 10.1002/1097-0142(19810815)48:4<873::AID-CNCR2820480402>3.0.CO;2-1
DO - 10.1002/1097-0142(19810815)48:4<873::AID-CNCR2820480402>3.0.CO;2-1
M3 - Article
C2 - 7272931
AN - SCOPUS:0019451241
SN - 0008-543X
VL - 48
SP - 873
EP - 875
JO - Cancer
JF - Cancer
IS - 4
ER -
