Abstract
The potential for targeting estrogen receptor (ER)-β in various cancer models has been gaining considerable attention in recent years. In this issue of the journal, Chaudhary and colleagues demonstrate markedly decreased ultraviolet B (UVB)-induced skin cancer in a mouse model using a highly specific ER-β agonist, ERB-041. The mechanisms that underlie this strong inhibitory effect are mediated by inhibition of proinflammatory signaling and epithelial-mesenchymal transition (EMT). The changes in EMT were due in part to modulation of WNT/β-catenin signaling. Collectively, the results from these studies provide important new insights into the mechanisms by which the ER-β agonist ERB-041 inhibits UVB-induced skin cancer and opens the door for future studies that could examine combinatorial approaches for UVB-dependent skin cancer chemoprevention.
Original language | English (US) |
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Pages (from-to) | 182-185 |
Number of pages | 4 |
Journal | Cancer Prevention Research |
Volume | 7 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2014 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research