Targeting estrogen receptor-β for the prevention of nonmelanoma skin cancer

Pei Li Yao, Frank J. Gonzalez, Jeffrey M. Peters

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The potential for targeting estrogen receptor (ER)-β in various cancer models has been gaining considerable attention in recent years. In this issue of the journal, Chaudhary and colleagues demonstrate markedly decreased ultraviolet B (UVB)-induced skin cancer in a mouse model using a highly specific ER-β agonist, ERB-041. The mechanisms that underlie this strong inhibitory effect are mediated by inhibition of proinflammatory signaling and epithelial-mesenchymal transition (EMT). The changes in EMT were due in part to modulation of WNT/β-catenin signaling. Collectively, the results from these studies provide important new insights into the mechanisms by which the ER-β agonist ERB-041 inhibits UVB-induced skin cancer and opens the door for future studies that could examine combinatorial approaches for UVB-dependent skin cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
JournalCancer Prevention Research
Issue number2
StatePublished - Feb 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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