Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng; Junxuan Lu

doi:10.4161/23723556.2014.974465

Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng, Junxuan Lu

Research output: Contribution to journal › Comment/debate › peer-review

20 Scopus citations

Abstract

Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

Original language	English (US)
Article number	e974465
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.974465
State	Published - Jul 3 2015

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

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10.4161/23723556.2014.974465

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title = "Targeting hexokinase 2 in castration-resistant prostate cancer",

abstract = "Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.",

author = "Yibin Deng and Junxuan Lu",

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AU - Lu, Junxuan

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AB - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

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Targeting hexokinase 2 in castration-resistant prostate cancer

Abstract

All Science Journal Classification (ASJC) codes

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